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Artigos da EINA - Deficiências

Distúrbios de Desenvolvimento Embriológico

Atrofias Cerebelares

O cerebelo foi sempre considerado uma estrutura cerebral envolvida com o controle da motricidade, sem participação importante nas atividades cognitivas. Essa posição mudou radicalmente nos últimos anos, pois as técnicas mais recentes de mapeamento da atividade cerebral têm mostrado o envolvimento do cerebelo em várias atividades cognitivas, como por exemplo a produção e compreensão da linguagem. Além disso, mostrou-se que o autismo se associa muito com alterações da estrutura fina do cerebelo.

A atrofia da camada granular é associada a Epilepsia, Microcefalia e retardo mental. Parece ter um caracter autossômico recessivo. Outras atrofias celulares podem estar associadas a outras patologias, como por exemplo, distúrbio do desenvolvimento embrionário como ausência do septo pellucidum e Macro Cisterna Magna, como nos casos ilustrados na figura.


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